What is NAD+?:
NAD, nicotinamide adenine dinucleotide, is a coenzyme involved in many bodily processes, such as regulating metabolism, DNA repair, disease prevention and the immune system. Studies have found that a decrease of NAD+ is directly related to signs of aging, neurodegeneration, metabolic diseases, and some forms of cancer.
In our body, we have proteins known as sirtuins. These proteins are in charge of regulating the lifespan and death of cells, controlling cell energy, and managing how our cells respond to stressors. Sirtuins are NAD+ dependent, meaning when our NAD+ levels are low, our sirtuin levels decline as well.
NAD+ and The Body:
Diabetes
Sirtuin proteins play a crucial role in maintaining normal blood sugar levels and preventing type 2 diabetes. They help control the release of insulin in response to glucose and protect tissues like fat, liver, and muscles from insulin resistance. Increasing sirtuin levels can improve glucose tolerance without affecting body weight, prevent kidney damage by reducing oxidative stress, and reduce inflammation due to diabetes.
Alzheimer’s disease
Alzheimer’s typically involves various problems in the brain like inflammation, damaged mitochondria, and increased oxidative stress. It has also been found that people with this disease have low levels of sirtuin proteins. A study concluded that higher levels of NAD+ and sirtuins are associated with memory preservation and cognitive functioning. Having higher levels of these proteins also supports the production of other beneficial proteins throughout the body.
Depression
Depression is a very complex mental illness linked to problems like
inflammation, brain cell communication issues, and metabolic problems. A study was conducted where they found that low levels of sirtuin proteins within the hippocampus (region of the brain) led to behaviours similar to depression. However, an increase in proteins was linked to antidepressant effects on the brain and body.
Anti Aging and Longevity
In recent years, there’s been a surge of interest in the interplay between NAD+, sirtuin levels, and illness. NAD+ (nicotinamide adenine dinucleotide) is a crucial molecule involved in various cellular processes, including energy metabolism and DNA repair. Sirtuins, a class of proteins dependent on NAD+, play a pivotal role in regulating cellular health and longevity. Research suggests that declines in NAD+ levels and impaired sirtuin function are associated with aging and age-related diseases, such as neurodegenerative disorders, metabolic conditions, and cardiovascular issues. Understanding the intricate relationship between NAD+ availability, sirtuin activity, and illness holds promise for developing novel therapeutic interventions to combat age-related decline and promote overall well-being.
Cognitive Health
As a coenzyme involved in cellular energy metabolism and DNA repair, NAD+ supports the healthy functioning of neurons and promotes synaptic plasticity, the brain’s ability to adapt and form new connections. Research suggests that NAD+ levels decline with age, contributing to cognitive decline and increased vulnerability to neurodegenerative diseases. By replenishing NAD+ levels through supplementation or lifestyle interventions, such as exercise and calorie restriction, it may be possible to mitigate age-related cognitive decline and support brain health.
In conclusion, NAD+ emerges as a crucial component in maintaining overall health and well-being, influencing various bodily processes ranging from metabolism regulation to disease prevention. The intricate interplay between NAD+ levels and sirtuin proteins underscores their significance in combating age-related decline and promoting longevity. At Reset Wellness Club in Aurora, our NAD+ vitamin therapy offers a proactive approach to optimizing NAD+ levels, supporting cognitive function, and enhancing overall vitality.